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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 2
1955 1
1958 1
1961 1
1966 1
1967 4
1968 6
1969 10
1970 5
1971 5
1972 9
1973 1
1974 3
1975 12
1976 17
1977 10
1978 11
1979 11
1980 15
1981 17
1982 20
1983 16
1984 27
1985 30
1986 26
1987 30
1988 19
1989 39
1990 39
1991 24
1992 29
1993 30
1994 29
1995 40
1996 40
1997 56
1998 51
1999 52
2000 54
2001 72
2002 87
2003 95
2004 113
2005 127
2006 152
2007 195
2008 221
2009 232
2010 229
2011 271
2012 290
2013 322
2014 316
2015 315
2016 311
2017 289
2018 316
2019 338
2020 373
2021 390
2022 349
2023 343
2024 118

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5,986 results

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Page 1
Hot-spot analysis for drug discovery targeting protein-protein interactions.
Rosell M, Fernández-Recio J. Rosell M, et al. Expert Opin Drug Discov. 2018 Apr;13(4):327-338. doi: 10.1080/17460441.2018.1430763. Epub 2018 Jan 29. Expert Opin Drug Discov. 2018. PMID: 29376444 Review.
This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational analysis and docking can help to locate the interface, molecular dynamics can be used to find suitable cavities, and hot-spot …
This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational …
Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.
Xie Z, Yu L, Li S, Li J, Liu Y. Xie Z, et al. BMC Oral Health. 2023 Jun 1;23(1):346. doi: 10.1186/s12903-023-03076-x. BMC Oral Health. 2023. PMID: 37264364 Free PMC article.
Standard mean difference (SMD) was used as the effect size for the Network meta-analysis (NMA). Consistency and inconsistency tests were conducted. ...Thirty-one of them, with a total of 1906 participants, were included in the network meta-analysis. The studies owne …
Standard mean difference (SMD) was used as the effect size for the Network meta-analysis (NMA). Consistency and inconsistency tests w …
Clinical effect of T-SPOT.TB test for the diagnosis of tuberculosis.
Ma Y, Li R, Shen J, He L, Li Y, Zhang N, Wu Q, Zhang J, Zheng J, Wang X. Ma Y, et al. BMC Infect Dis. 2019 Nov 21;19(1):993. doi: 10.1186/s12879-019-4597-8. BMC Infect Dis. 2019. PMID: 31752713 Free PMC article.
BACKGROUND: The goal of this study was to further investigate the clinical effectiveness of the T-SPOT.TB test in diagnosing tuberculosis (TB), including the effects of T-SPOT.TB test on evaluating diverse TB types and locations. METHODS: We collected …
BACKGROUND: The goal of this study was to further investigate the clinical effectiveness of the T-SPOT.TB test in diagnosing t …
Spot protein-creatinine ratio and spot albumin-creatinine ratio in the assessment of pre-eclampsia: a diagnostic accuracy study with decision-analytic model-based economic evaluation and acceptability analysis.
Waugh J, Hooper R, Lamb E, Robson S, Shennan A, Milne F, Price C, Thangaratinam S, Berdunov V, Bingham J. Waugh J, et al. Health Technol Assess. 2017 Oct;21(61):1-90. doi: 10.3310/hta21610. Health Technol Assess. 2017. PMID: 29064366 Free PMC article. Review.
There were four index tests on a spot sample of urine: (1) SPCR test (conducted at the local laboratory); (2) SPCR test [conducted at the central laboratory using the benzethonium chloride (BZC) assay]; (3) SPCR test [conducted at the central laborator …
There were four index tests on a spot sample of urine: (1) SPCR test (conducted at the local laboratory); (2) SPCR test …
Quantitative spot-test analysis of metformin in pharmaceutical preparations using ultraviolet-visible diffuse reflectance spectroscopy.
Tubino M, Bianchessi LF, Vila MM. Tubino M, et al. Anal Sci. 2010 Jan;26(1):121-4. doi: 10.2116/analsci.26.121. Anal Sci. 2010. PMID: 20065599 Free article.
A quantitative spot-test for the determination of metformin in pharmaceutical preparations using diffuse UV-visible reflectance is reported. ...The average RSD is 2.5% and the detection (0.009 mol L(-1)) and the quantitation (0.03 mol L(-1)) limits are quite adequat …
A quantitative spot-test for the determination of metformin in pharmaceutical preparations using diffuse UV-visible reflectanc …
Human Hazard Assessment Using Drosophila Wing Spot Test as an Alternative In Vivo Model for Genotoxicity Testing-A Review.
Pitchakarn P, Inthachat W, Karinchai J, Temviriyanukul P. Pitchakarn P, et al. Int J Mol Sci. 2021 Sep 14;22(18):9932. doi: 10.3390/ijms22189932. Int J Mol Sci. 2021. PMID: 34576092 Free PMC article. Review.
Genomic instability, one of cancer's hallmarks, is induced by genotoxins from endogenous and exogenous sources, including reactive oxygen species (ROS), diet, and environmental pollutants. A sensitive in vivo genotoxicity test is required for the identification of human ha …
Genomic instability, one of cancer's hallmarks, is induced by genotoxins from endogenous and exogenous sources, including reactive oxygen sp …
A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager.
Kim TY, Chang HE, Lee SW, Seo SH, Hong YJ, Park JS, Park KU. Kim TY, et al. PLoS One. 2019 Sep 25;14(9):e0222920. doi: 10.1371/journal.pone.0222920. eCollection 2019. PLoS One. 2019. PMID: 31553764 Free PMC article.
The agreement of qualitative test results was assessed using Cohen's kappa coefficient. The relationship of spot counts was studied using Bland-Altman analysis. RESULTS: The overall percent agreement of the qualitative test results was 95.43% with a ka …
The agreement of qualitative test results was assessed using Cohen's kappa coefficient. The relationship of spot counts was st …
Evaluation of the T-SPOT.TB test, oxidation-related factors, and antimicrobial peptide LL-37 in the diagnosis of pulmonary tuberculosis with type 2 diabetes.
Ma L, Chen X, Weng S, Yang X. Ma L, et al. J Int Med Res. 2021 Dec;49(12):3000605211064418. doi: 10.1177/03000605211064418. J Int Med Res. 2021. PMID: 34936829 Free PMC article.
OBJECTIVE: To investigate the diagnostic value of the T cell spot (T-SPOT.TB) test, oxidation-related factors (ORF), and antimicrobial peptide LL-37 in patients with pulmonary tuberculosis (PTB) with type 2 diabetes. ...Of these, 232 patients with PTB and typ …
OBJECTIVE: To investigate the diagnostic value of the T cell spot (T-SPOT.TB) test, oxidation-related factors (ORF), an …
A review of chemical 'spot' tests: A presumptive illicit drug identification technique.
Philp M, Fu S. Philp M, et al. Drug Test Anal. 2018 Jan;10(1):95-108. doi: 10.1002/dta.2300. Epub 2017 Nov 10. Drug Test Anal. 2018. PMID: 28915346 Review.
Today, color tests face many challenges, from the appearance of new psychoactive substances to concerns regarding selectivity, sensitivity, and safety. Advances in technology have seen color test reagents used in digital image color analysis, solid sensors, and micr …
Today, color tests face many challenges, from the appearance of new psychoactive substances to concerns regarding selectivity, sensitivity, …
A study of the validity of the Six-Spot Step Test in ambulatory people with Parkinson's disease.
Brincks J, Callesen J, Johnsen E, Dalgas U. Brincks J, et al. Clin Rehabil. 2019 Jul;33(7):1206-1213. doi: 10.1177/0269215519833016. Epub 2019 Feb 25. Clin Rehabil. 2019. PMID: 30798635
SUBJECTS: Fifty-eight people with Parkinson's disease. MAIN MEASURE: The Six-Spot Step Test, the Timed "Up and Go" test, the mini-Balance Evaluation Systems Test (mini-BESTest), and postural sway were tested on the same day, and the Spearman's Rank Cor …
SUBJECTS: Fifty-eight people with Parkinson's disease. MAIN MEASURE: The Six-Spot Step Test, the Timed "Up and Go" test …
5,986 results